Friday, May 10, 2019  8:00 am – 11:30 am  Ballroom 20D  

Major Symposium A: Interactions of Innate and Adaptive Immune Cells that Promote Autoimmunity

Chairs:

• David A. Hafler, Yale Univ.
• Melissa A. Brown, Feinberg Sch. of Med., Northwestern Univ.

Speakers:

• David A. Hafler, Yale Univ., Finding the culprit in human autoimmune disease
• Melissa A. Brown, Feinberg Sch. of Med., Northwestern Univ., How testosterone shapes T cell responses in neuroinflammatory disease
• Maureen Su, Univ. of North Carolina, Chapel Hill, Blaming the victim: target tissues in the autoimmune response
• Jane Buckner, Benaroya Res. Inst., T cell intrinsic and extrinsic factors determine the function of Tregs in autoimmunity
• Mandy McGeachy, Univ. of Pittsburgh, Th17 functions in mouse and man
• Vijay K. Kuchroo, Brigham and Women’s Hosp., Th17 cells and induction of tissue inflammation

Friday, May 10, 2019  8:00 am – 11:30 am  Ballroom 20BC  

Major Symposium B: Extrinsic and Intrinsic Immune Aspects of the Tumor Microenvironment

Chairs:

• Victor H. Engelhard, Univ. of Virginia
• Mary Jo Turk, Dartmouth Geisel Sch. of Med.

Speakers:

• Victor H. Engelhard, Univ. of Virginia, Immune cell infiltration and tertiary lymphoid structures as determinants of antitumor immunity
• Mary Jo Turk, Dartmouth Geisel Sch. of Med., Tissue-resident memory T cell responses to cancer
• Jennifer A. Wargo, MD Anderson Cancer Ctr., The role of the microbiome in response and toxicity to cancer therapy
• Max Krummel, Univ. of California, San Francisco, Visualization and class discovery of tumoral immune systems – beyond checkpoint blockade
• Susan M. Kaech, Salk Inst., Metabolic regulation of anti-tumor immunity
• Jose R. Conejo-Garcia, H. Lee Moffitt Cancer Ctr. and Res. Inst., Protective spontaneous humoral responses in ovarian cancer

Friday, May 10, 2019  8:00 am – 10:00 am  

Block Symposia

Room 31ABCCellular Mechanisms of Innate Immunity 1

Room 26ABFrom There to Here, from Here to There: Inflamed Things Are Everywhere

Room 33ABCHIV/SIV Vaccine/Immunotherapy and Impact of HIV/SIV Infection in Antigen-Specific Immunity

Room 30ABInnate Immune Mechanisms

Room 25ABCInnate Lymphocyte Development, Stroma, and Aging

Friday, May 10, 2019  9:00 am – 10:00 am  Room 32AB  

How to Convert Your CV into a Résumé

Speaker:

• Derek Haseltine, Director, Career Develop. Ctr., Baylor Col. of Med.

For anyone seeking a job outside of academe, how you present yourself on paper is critical. A well-prepared résumé can make all the difference in securing that interview. The focus of this session will be on the important elements of a résumé, the differences between a résumé and the standard academic curriculum vitae, and the information needed to make a good impression. In this special career development session, attendees will be instructed in how to transform their CVs into professional résumés. Small breakout sessions for individual consulting will follow. Bring your CV!

Friday, May 10, 2019  10:15 am – 11:45 am  Room 26AB  

Advocating for Biomedical Research: We’ve Done it and So Can You!

Sponsored by the AAI Committee on Public Affairs (CPA)

Chair:

• David D. Chaplin, Univ. of Alabama at Birmingham, AAI Committee on Public Affairs Chair

Speakers:

• Wayne M. Yokoyama, Washington Univ. Sch. Of Med. in St. Louis
• Pamela J. Fink, Univ. of Washington
• Lisa A. Borghesi, Univ. of Pittsburgh
• Jason P. Gigley, Univ. of Wyoming
• Mariana Guerra-Maupome, Iowa State Univ. Col. of Vet. Med.

A 2017 report by the Congressional Management Foundation supports what we at AAI have long believed: that advocacy is important and effective, and that direct interactions between constituents and lawmakers/their staffs are especially influential. Consistent, strong advocacy has played an essential role in persuading Congress to increase the NIH budget by $9 billion over the last four years and to reject a harmful provision that could have significantly increased taxes on graduate students. But how can you, as a working scientist, help ensure that supporting biomedical research, NIH, and the needs of researchers remain top Congressional priorities?
 
This session will explore key questions like why, how, and when you should advocate for biomedical research. It will also feature a panel of immunologists from various careers stages who have engaged in advocacy in a variety of interesting and unique ways. These researchers will share their experiences and then welcome questions from the audience.

Friday, May 10, 2019  10:15 am – 12:15 pm  Room 25ABC  

Society for Mucosal Immunology (SMI) Symposium: Combating Pathogens at Mucosal Surfaces

Chairs:

• Lauren A. Zenewicz, Univ. of Oklahoma Hlth. Sci. Ctr.
• Jennifer Lund, Fred Hutchinson Cancer Res. Ctr.

Speakers:

• Amanda Jamieson, Brown Univ., Protecting the lung despite the costs through innate immune triage mechanisms
• Jacob Kohlmeier, Emory Univ., The rise and fall of lung-resident T cell memory
• Donna Farber, Columbia Univ., Development of mucosal resident memory T cells
• Jennifer Lund, Fred Hutchinson Cancer Res. Ctr., Regulation of immunity to virus infection in the genital tract

Friday, May 10, 2019  10:15 am – 12:15 pm  Room 30AB  

The International Society of Comparative and Developmental Immunology (ISDCI) Symposium: Deuterostome Immune Innovations from Echinoderms to Mammals

Chairs:

• Mike Criscitiello, Texas A&M Univ.
• Tony de Tomaso, Univ. of California, Santa Barbara

Speakers:

• Catherine Schrankel, Univ. of California, San Diego, Evolution of leukocytes transcriptional development in the sea urchin
• Tony de Tomaso, Univ. of California, Santa Barbara, Primordial histocompatibility in a colonial tunicate
• Jonathan Rast, Emory Univ., Lamprey variable lymphocytes receptors
• Vaughn Smider, Scripps Res. Inst., Cattlebodies expand paratope possibilities

Friday, May 10, 2019  10:15 am – 12:15 pm  

Block Symposia

Room 30CDEHematopoietic Stem Cell Transplantation: All of Immunology Occurring in One Model

Room 31ABCRegulation of Innate and Cytotoxic Lymphocyte Responses: Molecular Mechanisms

Room 33ABCViruses, CD8⁺ T cells, and Natural Killers

Friday, May 10, 2019  11:00 am – 1:00 pm  Room 32AB  

Immunology Teaching Interest Group

Sponsored by the AAI Education Committee

Chairs:

• Anil K. Bamezai, Villanova Univ.
• Stephanie James, Regis Univ. Sch. of Pharmacy

Panelists:

• Michelle Snyder, Towson Univ., Student outcomes in a CURE course using simple model organisms to characterize host-pathogen interactions
• Laurie Shornick, Saint Louis Univ., Using an entrepreneurial mindset activity to create value in an immunobiology course
• John Frelinger, Univ. of Rochester, Immunology “hooks”: strategies to increase student engagement
• William Carr, Medgar Evers Col., City Univ. of New York, Using “Pillars of Immunology” research articles to enhance problem-solving skills among undergraduate students at a Predominantly Black Institution

Breakout Session Leaders:

• Deborah Brown, Univ. of Nebraska, Lincoln, JiTT strategies and student outcomes
• Devavani Chatterjea, Macalester Col., Ready to talk about it? A toolkit for reading and discussing scientific papers in undergraduate immunology classrooms
• Nicholas Pullen, Univ. of Northern Colorado, Authentic science engagement: toward a CURE for undergraduate immunology
• Kara Lukin, Univ. of Colorado, Denver, Jeffrey Novack, Col. of Med., Pacific Northwest Univ., and Sarah Redmond, Radford Univ., Using case studies across the immunology curriculum

Are you looking for new ideas or strategies to enliven and improve your teaching? If so, please join us for this special interest group which will focus on strategies that instructors can use to successfully convey immunology concepts to students at the undergraduate and graduate level. The session will explore the use of course-based undergraduate research experiences (CURE), just in time teaching (JiTT), research articles, entrepreneurial mindset activities, and more through talks and structured breakout discussion groups. Current educators, new faculty, and trainees with an interest in teaching are welcome.

Friday, May 10, 2019  11:45 am – 2:15 pm  Ballroom 20A  

Careers Roundtable and Speed Networking Session

Sponsored by the AAI Minority Affairs Committee (MAC)

Chair:

• Robert J. Binder, Univ. of Pittsburgh; AAI Minority Affairs Committee Chair

Networking skills have never been more crucial to ensure success for early/mid-career scientists, including those traditionally under-represented in biomedical research. At the roundtable, take advantage of the opportunity to meet in small-group format with accomplished, senior immunologists to hear how they have handled the career challenges you now face and learn what they believe will work for you today. Then, practice networking in a relaxed environment offering a structured networking exercise and personalized feedback on communicating your scientific interests/objectives most effectively. Scientists and trainees of all backgrounds are encouraged to attend! Registration Fee: $30 (Includes coffee break.)

Discussion topics and table leaders:

Grad Student: finding a mentor, setting sights on postdoc training

• Table Leaders: Robert J. Binder, Univ. of Pittsburgh; Luis A. Sanchez-Perez, Duke Univ.; Tonya Webb, Univ. of Maryland; Santiago Partida-Sanchez, Ohio State Univ.

Postdoc: finding a mentor, setting sights on a faculty position

• Table Leaders: Mireia Guerau-de-Arellano, Ohio State Univ.; C. Henrique Serezani, Vanderbilt Univ.; Avery August, Cornell Univ.

Junior Faculty: preparing for promotion and tenure

• Table Leaders: Margaret S. Bynoe, Cornell Univ.; Prosper Boyaka, Ohio State Univ.

Work-life balance, it’s real!

• Table Leader: Claudia Jakubzick, Natl. Jewish Hlth.

Academia or Industry: how to decide (or switch sides)

• Table Leaders: Homero Sepulveda, Thermo Fisher Scientific; Cherié Butts, Biogen; Jonathan A. Deane, GNF/Novartis; Louis Gonzalez, Shattuck Labs

Government Agency Careers:

• Table Leaders: Jennifer Martinez, NIEHS, NIH; Marta Catalfamo, Georgetown Univ.

Non-Bench-Research Science Careers – e.g., entrepreneurship/research technology; non-profits/foundations; intellectual property/patent law

• Table Leaders: Robert Balderas, BD Biosciences; James W. Lillard, Morehouse Sch. of Med. and JYANT Technologies; Thandi Onami, Gates Fndn.; Gregory P. Einhorn, Greer, Burns and Crain, Ltd.

Friday, May 10, 2019  12:30 pm – 2:30 pm  Room 26AB  

Towards One Health: Understanding Disease with Animal Models

Sponsored by the AAI Veterinary Immunology Committee

Support in part provided by the American Association of Veterinary Immunologists (AAVI)

Chairs:

• Crystal Loving, Natl. Animal Dis. Ctr., ARS, USDA, AAI Veterinary Immunology Committee Chair
• Alan J. Young, South Dakota State Univ., AAVI President

Speakers:

• John P. Driver, Univ. of Florida, The pig as a translational model to evaluate NKT cell therapy
• Jodi L. McGill, Iowa State Univ., Use of the neonatal calf for development of novel intervention strategies to reduce and prevent respiratory syncytial virus infection
• Adam J. Moeser, Michigan State Univ., Early life stress impacts lifelong immune function, but how? Studying piglets may shed light
• Irene Salinas, Univ. of New Mexico, Rainbow trout as model for understanding neuroimmune interactions at the nasal mucosa

One Health is an approach to ensure the well-being of people, animals, and the environment through collaborative problem solving and interdisciplinary collaboration. Many of the microbes and environmental stressors that impact humans also impact animals, as they overlap in many of the same ecosystems. The intent of this symposium is to present research in animal models that provide important discoveries and findings for improving both human and animal health. The symposium will feature research in pigs, neonatal cattle, and fish and will span topics of stress, interventions, therapy, and neuroimmune interactions. It will showcase commonalities between human and animal health, and highlight the value of One Health approach for understanding immunity and enhancing disease resilience.

Friday, May 10, 2019  12:30 pm – 2:30 pm  Room 33ABC  

The American Society of Transplantation (AST) Symposium: Teaching Old Dogmas New Tricks: Novel Functions of Macrophages and Dendritic Cells

Chairs:

• David Rothstein, Univ. of Pittsburgh
• Anita Chong, Univ. of Chicago

Speakers:

• • Fadi Lakkis, Univ. of Pittsburgh, Innate allorecognition drives allograft rejection
  • Ankit Bharat, Northwestern Univ., Donor pulmonary monocytes and allograft dysfunction
  • Thalachallour Mohanakumar, Univ. of Arizona, Donor alveolar macrophages mediate chronic lung allograft rejection
  • Xunrong Luo, Duke Univ., Tolerogenic macrophages in the spleen and heart

Friday, May 10, 2019  12:30 pm – 2:30 pm  Room 25ABC  

The American Society of Tropical Medicine and Hygiene (ASTMH) Symposium: Immune Responses to Parasites

Chairs:

• Robin Stephens, Univ. of Texas Med. Br., Galveston
• Francis M. Ndungu, KEMRI-Wellcome Trust Res. Programme, Kenya

Speakers:

• Margaret E. Feeny, Univ. of California, San Francisco Med. Ctr., αβ and γδ T cells and cytokines in the regulation of the immune response to P. falciparum malaria
• De’Broski Herbert, Univ. of Pennsylvania Sch. of Vet. Med., LINGO proteins: a new language for the mucosal barrier
• Francis M. Ndungu, KEMRI-Wellcome Trust Res. Programme, Kenya, From mouse to man to vaccine: B cell memory to malaria
• Christine S. Hopp, NIH, NIAID, Ex vivo analysis of P. falciparum-specific B cell responses to natural malaria infection in children and adults

Friday, May 10, 2019  12:30 pm – 2:30 pm  

Block Symposia

Ballroom 20DCellular Therapies for Cancer

Room 30CDECytokines Regulating Inflammation

Room 31ABCCytoplasmic Sensing

Friday, May 10, 2019  1:00 pm – 2:30 pm  Room 30AB  

AAI Business Meeting

Chair:

• M. Michele Hogan, Executive Director, AAI

AAI reports on the “state of the association” to its members at every AAI annual meeting. Members will hear from the Executive Director, the Secretary-Treasurer, the Editors-in-Chief of AAI journals (The Journal of Immunology and ImmunoHorizons), and the Chair of the Committee on Public Affairs on the financial standing of AAI and other matters of importance to the membership. Selected 2019 AAI awards will also be presented during this session.

Friday, May 10, 2019  1:00 pm – 2:30 pm  Room 30AB  

AAI Distinguished Service Award Presentation

Chair:

• M. Michele Hogan, Executive Director, AAI

Award Recipients:
Beth A. Garvy
Univ. of Kentucky Chandler Med. Ctr.
For outstanding service to AAI and the immunology community as member and Chair of the AAI Committee on Public Affairs, 2011-2018

Clinton B. Mathias
Western New England Univ.
For outstanding service to AAI and the immunology community as as Director of the AAI High School Teachers Program, 2012-2018

Friday, May 10, 2019  1:00 pm – 2:30 pm  Room 30AB  

AAI-Thermo Fisher Trainee Achievement Award

To recognize promising trainees in the field of immunology

Billur Akkaya, M.D., D.Phil., NIAID, NIH
Lalit Beura, B.V.Sc., Ph.D., Univ. of Minnesota
Meng Deng, B.D.S., M.S., Univ. of North Carolina, Chapel Hill
Robert Haines, Emory Univ.
Simone L. Park, Ph.D., Univ. of Melbourne, Australia
Derek J. Theisen, Washington Univ. in St Louis

Friday, May 10, 2019  1:00 pm – 2:30 pm  Room 30AB  

Pfizer-Showell Travel Award

To recognize the professional promise of an early-career investigator

Si Ming Man
Australian Natl. Univ.

Friday, May 10, 2019  1:00 pm – 2:30 pm  Room 30AB  

Chambers-Thermo Fisher Scientific Award

To advance the career of an early-career scientist who attends the AAI annual meeting and presents an outstanding abstract specifically in the area of cancer biology

Chunwan Lu
Med. Col. of Georgia, Augusta Univ.
 

Friday, May 10, 2019  1:00 pm – 2:30 pm  Room 30AB  

Lefrançois-BioLegend Award

To advance the career of a trainee who attends the AAI annual meeting and presents an outstanding abstract specifically in the area of mucosal immunology

Scott M. Anthony
Univ. of Iowa

Friday, May 10, 2019  1:00 pm – 2:30 pm  Room 30AB  

Lustgarten-Thermo Fisher Scientific Award

To advance the career of a mid-career scientist who attends the AAI annual meeting and presents an outstanding abstract specifically in the area of immune regulation

Matam Vijay-Kumar
Univ. of Toledo Col. of Med. and Life Sci.

Friday, May 10, 2019  3:45 pm – 5:45 pm  Room 33ABC  

Obtaining Deep Mechanistic Insights from and into the Human System

Sponsored by the AAI Clinical Immunology Committee

Chairs:

• Jordan S. Orange, Columbia Univ. Med. Ctr., AAI Clinical Immunology Committee Chair
• Veena Taneja, Mayo Clin.

Speakers:

• Megan A. Cooper, Washington Univ. Sch. of Med. in St. Louis, Immune dysregulation with STAT3 gain-of-function
• Janet Chou, Harvard Med. Sch., Novel immunodeficiencies from the ICID network
• Mark S. Anderson, Univ. of California, San Francisco, Central immune tolerance and human autoimmunity
• Helen Su, NIAID/NIH, Elucidating molecular mechanisms of a novel inherited immunodeficiency-immunodysregulation disorder

The study of human disease has always provided the opportunity to derive unconventional insights into immunology. Current genomic technologies and cutting-edge biological approaches have not only made these opportunities more accessible, but they are being brought to bear with greater frequency and impact. Aberrant human immunity owing to inherent genetic influence can result in immunodeficiency, immunodysregulation, autoimmunity, autoinflammation or blends of these clinical expressions. The faculty of this session have made seminal contributions understanding how aberrant immunity causes clinical disease while providing profound mechanistic insights into how the human immune system works.

Friday, May 10, 2019  3:45 pm – 5:45 pm  Room 25ABC  

National Institute of Allergy and Infectious Diseases (NIAID) Symposium: Imaging Tissue-Specific Immunity

Chairs:

• Joseph J. Breen, NIAID, NIH
• Deborah Fowell, Univ. of Rochester

Speakers:

• Deborah Fowell, Univ. of Rochester, T cell navigation within inflamed skin
• Garry Nolan, Stanford Univ., Immune pathology from the molecular scale on up
• Rodrigo Gonzalez, Harvard Univ., Microscopy imaging of cellular immune responses in the nasal mucosa
• Christopher Hunter, Univ. of Pennsylvania, Host-pathogen interactions that leads to T cell priming

Friday, May 10, 2019  3:45 pm – 5:45 pm  Room 26AB  

German Society for Immunology (DgFI) Symposium: Nucleic Acid Immunity

Chairs:

• Gunther Hartmann, Univ. of Bonn, Germany
• Veit Hornung, Univ. of Munich, Germany
• Axel Roers, Technische Universität Dresden, Germany

Speakers:

• Thomas Kamradt, Univ. of Jena , Germany, German Society of Immunology
• Gunther Hartmann, Univ. of Bonn, Germany, Cooperation of DNases and cGAS in immune sensing of DNA
• Axel Roers, Technische Universität Dresden, Germany, Mechanisms of pathogenic chronic activation of intracellular DNA sensing
• Veit Hornung, Univ. of Munich, Germany, DNA-induced inflammasome activation
• Martin Schlee, Univ. of Bonn, Germany, RNA modifications impairing the RIG-I pathway
• Andrea Ablasser, École Polytechnique Fédérale de Lausanne, Switzerland, Insights into innate DNA sensing through the cGAS-STING pathway
• Min Ae Lee-Kirsch, Technische Universität Dresden, Germany, Therapeutic approaches to type 1 interferonopathies

Friday, May 10, 2019  3:45 pm – 5:45 pm  

Block Symposia

Room 31ABCB Cells and Tfh Cells

Room 30CDEBasic Autoimmunity: Immunoregulation

Room 32ABCD4⁺ T Cell Differentiation and Function

Room 30ABNovel Strategies and Their Functions for Preventing Respiratory Infections

Room 29ABCDResident Memory in Tumor Immunotherapy

Friday, May 10, 2019  4:30 pm – 5:30 pm  Ballroom 20BCD  

AAI-BD Biosciences Investigator Award Presentation and Lecture

Generously supported by BD Biosciences

Chair:

• JoAnne L. Flynn, Univ. of Pittsburgh Sch. of Med., AAI President

Award Recipient:
Francisco J. Quintana
Brigham and Women’s Hosp., Harvard Med. Sch.
Environmental control of CNS inflammation
 
AAI President JoAnne L. Flynn and Robert Balderas, Vice President of Biological Sciences and Market Development, BD Biosciences, will introduce the awardee and present the award immediately prior to Dr. Quintana’s lecture.
 
The AAI-BD Biosciences Investigator Award recognizes an early-career investigator who has made outstanding contributions to the field of immunology.

Friday, May 10, 2019  6:00 pm – 6:45 pm  Ballroom 20BCD  

Distinguished Lecture—Andrea J. Tenner: Complement: primitive yet powerful—new discoveries in immunity and the nervous system

Andrea J. Tenner
Univ. of California, Irvine
Complement: primitive yet powerful–new discoveries in immunity and the nervous system

Friday, May 10, 2019  7:00 pm – 9:00 pm  Room 32AB  

Careers in Biotech: Panel Discussion and Networking

Sponsored by the AAI Education Committee

Generously supported by the Allen Institute for Immunology

Chair:

• Kerry A. Casey, Allen Inst. for Immunology

Panelists:

• Cherié L. Butts, Associate Medical Director, Biogen
• Steve Crampton, Senior Scientist, Pharmacology & Immunology, aTyr Pharma, Inc.
• Luisa Salter-Cid, Chief Scientific Officer, Gossamer Bio
• Karsten Sauer, Vice President, Immunology, Torque Therapeutics

Many opportunities exist in biotechnology for scientists with advanced degrees. There are positions in laboratory research, program management, business development, regulatory affairs, clinical trials oversight, medical liaison, and more. This panel features scientists employed in a variety of positions discussing their career paths and the skills required for success in each. Following the panel discussion, enjoy casual conversation with the speakers and other scientists from biotech at a networking reception.

Friday, May 10, 2019  7:00 pm – 10:00 pm  

The AAI Journals Editorial Boards Dinner and Meeting (By Invitation Only)

Generously sponsored by Sheridan Journal Services

Members of the AAI editorial boards and Publication Committee meet to discuss issues pertaining to AAI publications, The Journal of Immunology and ImmunoHorizons, as well as general issues faced by scientific publishing.

Saturday, May 11, 2019  8:00 am – 11:30 am  Ballroom 20D  

Major Symposium C: Acute and Chronic Inflammation

Chairs:

• Claudia Kemper, NHLBI, NIH
• Michael C. Carroll, Boston Children’s Hosp.

Speakers:

• Claudia Kemper, NHLBI, NIH, An unexpected key role for the complosome in cell metabolism
• Michael C. Carroll, Boston Children’s Hosp., Functional importance of allelic differences in human complement C4A and C4B in inflammatory disease
• Jörg Köhl, Univ. of Lübeck, Germany, Non-canonical functions of complement in inflammatory diseases
• Clare E. Bryant, Univ. of Cambridge, England, Pattern recognition receptor signalling in response to bacterial infection
• Grace Y. Chen, Univ. of Michigan, Regulation of intestinal inflammation by NLRs and the gut microbiota
• Susan Carpenter, Univ. of California, Santa Cruz, The how and why of lncRNA function during inflammation

Saturday, May 11, 2019  8:00 am – 11:30 am  Ballroom 20BC  

Major Symposium D: Structural and Cellular Aspects of Innate Lymphocytes

Chairs:

• Erin J. Adams, Univ. of Chicago
• Joseph Sun, Mem. Sloan Kettering Cancer Ctr.

Speakers:

• • Erin J. Adams, Univ. of Chicago, Molecular recognition by immune receptors
  • Joseph Sun, Mem. Sloan Kettering Cancer Ctr., Epigenetic and transcriptional control of innate lymphocytes
  • Luc Teyton, Scripps Res. Inst., Structural anatomy of the T cell receptor complex: towards understanding of function
  • Catherine Blish, Stanford Univ., Tuning the natural killer response
  • Mariapia A. Degli-Esposti, Univ. of Western Australia, Australia, Innate lymphocyte responses to viral infection

Saturday, May 11, 2019  8:00 am – 10:00 am  Room 26AB  

Chinese Society of Immunology, Taiwan (CSIT) Symposium: Host Defense Against Microbial Infection

Chairs:

• Jenny Ting, Univ. of North Carolina
• Shie-Liang Hsieh, Academia Sinica, Taiwan

Speakers:

• Shie-Liang Hsieh, Academia Sinica, Taiwan, Targeting siglec for immunotherapy against HBV infection
• Mi-Hua Tao, Academia Sinica, Taiwan, Cure chronic HBV infection via targeting adaptive immune response: a critical role of CD4⁺ T cells
• Hung-Chih Yang, National Taiwan Univ. Hosp., Biodegradable nanoparticle co-encapsulating peptides and CpG elicits protective T cell immunity against lethal influenza viral infection
• Chung-Yi Wu, Academia Sinica, Taiwan, New method for the development of glycoconjugate bacterial vaccines using bacteriophages
• Tse-Hua Tan, Natl. Hlth. Res. Inst., Taiwan, MAP4K family kinases in T cell-mediated inflammation

Saturday, May 11, 2019  8:00 am – 10:00 am  

Block Symposia

Room 32ABBasic Autoimmunity: T Cells

Room 31ABCCellular Mechanisms of Innate Immunity 2

Room 33ABCImmune Development at Mucosal Sites

Room 30CDEMolecular Mechanisms of Helper T Cell Differentiation

Room 29ABCDNew Treatments for Autoimmune Arthritis and Skin Disease

Room 30ABTechnological Innovations II

Room 25ABCViruses and the T Cell Response

Saturday, May 11, 2019  10:15 am – 11:15 am  Room 32AB  

Interviewing for a Job

Speaker:

• Derek Haseltine, Director, Career Development Center, Baylor Col. of Med.

This session will be focused on tips and techniques to help you successfully navigate the interview process. Emphasis will be on how you can present yourself in the best possible light. You will also learn how to respond to unexpected questions. This session is open to anyone but is especially intended for student and postdoctoral attendees.

Saturday, May 11, 2019  10:15 am – 12:15 pm  Room 33ABC  

Fostering Diversity and Preventing Harassment in the Biomedical Research Workforce

Sponsored by the AAI Committee on Public Affairs (CPA), the AAI Minority Affairs Committee (MAC), and the AAI Committee on the Status of Women (CSOW)

Chairs:

• David D. Chaplin, Univ. of Alabama at Birmingham, AAI Committee on Public Affairs Chair
• Robert J. Binder, Univ. of Pittsburgh, AAI Minority Affairs Committee Chair
• Laura A. Solt, The Scripps Res. Inst., AAI Committee on the Status of Women Chair

Speakers:

• Elizabeth L. Hillman, President, Mills College; and Member, Committee on the Impacts of Sexual Harassment in Academia, National Academies of Science, Engineering, and Medicine, Sexual harassment in academia: the NASEM report and recommendations
• Hannah A. Valantine, Chief Officer for Scientific Workforce Diversity, NIH, NIH’s scientific approach to inclusive excellence
• Avery August, HHMI Professor; Professor of Immunology and Vice Provost for Academic Affairs, Cornell Univ., What can academic institutions do to address diversity and inclusion?

AAI believes that science thrives when all scientists thrive. And while the current biomedical research workforce is more diverse and welcoming than ever before, it is insufficiently diverse—and all too often unwelcoming—to female and underrepresented minority scientists. Both the federal government through its Government Accountability Office (GAO), and the National Academies of Sciences, Engineering, and Medicine (NASEM), have recently spoken out on these concerns. An August 2018 GAO report examines progress that the NIH has made in increasing the diversity of the biomedical research workforce and challenges NIH to do more. And a June 2018 NASEM report, entitled “Sexual Harassment of Women, Climate, Culture, and Consequences in Academic Sciences, Engineering, and Medicine,” describes continuing “biases and barriers,” including sexual harassment, that are faced by women scientists, and recommends ways to combat the problem.
 
This session will explore NIH actions to strengthen the diversity of the biomedical research workforce and address recommendations highlighted by the GAO report. It will also focus on the NASEM report, and delve into a key finding: “Diverse, inclusive, and respectful academic environments are environments where careers flourish, but sexual harassment does not.”

Saturday, May 11, 2019  10:15 am – 12:15 pm  Room 25ABC  

National Institute of Environmental Health Sciences (NIEHS) Symposium: The Missing Link: Our Environment and Immune Mediated Diseases

Chairs:

• Michael C. Humble, NIEHS, NIH
• Celine Beamer, Univ. of Montana

Speakers:

• Celine Beamer, Univ. of Montana, Involvement of aryl hydrocarbon receptor in thymic ILC function and regulation
• Michael Laiosa, Univ. of Wisconsin, Milwaukee, Regulation of cellular energetics by the aryl hydrocarbon receptor during hematopoiesis
• Susan McKarns, Univ. of Missouri, Columbia, Aryl hydrocarbon receptor on CD4⁺ T cell differentiation and autoimmune disease
• David Sherr, Boston Univ., The aryl hydrocarbon receptor as a driver of cancer and immunosuppression

Saturday, May 11, 2019  10:15 am – 12:15 pm  Room 26AB  

Korean Association of Immunologists (KAI) and Association of Korean Immunologists in America (AKIA) Symposium: Host and Microbial Factors Shaping Adaptive Immunity

Chairs:

• Aekyung Yi, Univ. of Tennessee Hlth. Sci. Ctr.
• Eui-Cheol Shin, Korea Adv. Inst. of Sci. and Technol., Korea

Speakers:

• Eui-Cheol Shin, Korea Adv. Inst. of Sci. and Technol., Korea, Characteristics and regulation of human liver resident T cells
• Insoo Kang, Yale Univ., The role of cytokine receptors in defining human T cell subsets
• Cheong-Hee Chang, Univ. of Michigan, Regulation of T cell metabolism by promyelocytic leukemia zinc finger (PLZF)
• Soohyun Kim, Konkuk Univ., Korea, Proinsulin shares a motif with IL-1a and induces inflammatory cytokine via IL-1R1

Saturday, May 11, 2019  10:15 am – 12:15 pm  

Block Symposia

Room 31ABCEpigenetic and Metabolic Regulation of Immunity

Room 30ABI’m on Fire: Local Control of Tissue Inflammation

Room 30CDEInnate and Adaptive Control of Allograft Rejection

Room 29ABCDMacrophages and Myeloid and Dendritic Cells in Tumor Immunity and Immunotherapy

Saturday, May 11, 2019  12:30 pm – 1:30 pm  Room 25ABC  

AAI-BioLegend Herzenberg Award Presentation and Lecture

Generously supported by BioLegend

Chair:

• JoAnne L. Flynn, Univ. of Pittsburgh Sch. of Med., AAI President

Award Recipient:

Frederick W. Alt
HHMI, Boston Children’s Hosp.
The fundamental role of chromatin loop extrusion in antibody diversification

AAI President JoAnne L. Flynn and Leonore A. Herzenberg, Stanford Univ. Sch. of Med., will introduce the awardee and present the award immediately prior to Dr. Alt’s lecture.

The AAI-BioLegend Herzenberg Award recognizes outstanding research contributions to the field of immunology in the area of B cell biology.

Saturday, May 11, 2019  12:30 pm – 2:00 pm  Ballroom 20A  

Careers in Science Roundtable

Sponsored by the AAI Education Committee & AAI Committee on the Status of Women (CSOW)

Chair:

• Laura A. Solt, Scripps Res. Inst.; AAI Committee on the Status of Women Chair

At this popular session, attendees will have the opportunity to meet with experienced scientists to explore specific career issues important to men and women in science today. Gain insights into issues you are confronting in your own career. Topics include international opportunities in science, succeeding in graduate school, participating in NIH Study Sections, considerations for scientists in M.D.-Ph.D. careers, and exciting careers beyond the bench. New to the 2019 session are topics on balancing teaching and research and careers in veterinary immunology. There are also table discussions on navigating work-life issues, such as balancing careers with family and transitioning from specific career stages, which may be relevant to any work environment (academic research, biotech industry, governmental agencies, non-profit). Don’t miss this great networking opportunity! Registration Fee: $30 (lunch included)

Discussion topics and table leaders:

Research Careers in Academia

• Succeeding in Graduate School
  Table Leaders: Lori R. Covey, Rutgers Univ.; Ann Griffith, Univ. of Texas Hlth. San Antonio
  • Graduate Student to Postdoc: finding a postdoc, interviewing
    Table Leaders: Lyse A. Norian, Univ. of Alabama, Birmingham; Lisa K. Denzin, Child Hlth. Inst. of New Jersey, Rutgers; Tyler K. Ulland, Univ. of Wisconsin; Steven Templeton, Indiana Univ. Sch. of Med.
• Postdoc to PI:
  • Government Research Institutions
    Table Leaders: Dorian McGavern, NINDS, NIH
  • Medical Schools
    Table Leaders: Lauren A. Zenewicz, Univ. of Oklahoma Hlth. Sci. Ctr.; Carrie L. Lucas, Yale Univ.
  • Undergraduate Institutions
    Table Leaders: Matthew R. Olson, Purdue Univ.
• New PI:
  • Recruiting Students and Postdocs
    Table Leaders: Irene Salinas, Univ. of New Mexico; Aimee M. Beaulieu, Rutgers Univ.
  • Preparing for Promotion
    Table Leaders: Louis B. Justement, Univ. of Alabama, Birmingham; Linda A. Sherman, Scripps Res. Inst.
  • Tips for Balancing Teaching and Research
    Table Leaders: Bao Q. Vuong, City Col. of New York
• Negotiating an Academic Position
  Table Leaders: Gudrun Debes, Thomas Jefferson Univ.; William R. Green, Dartmouth Univ. Geisel Sch. of Med.
• Mentoring Effectively
  Table Leaders: Amanda M. Jamieson, Brown Univ.; Lisa C. Osborne, Univ. of British Columbia
• How to Build a Network for Postdocs
  Table Leaders: Laura A. Solt, Scripps Res. Inst.; Juliet Morrison, Univ. of California, Riverside
• Networking Skills for PIs
  Table Leaders: Jeremy M. Boss, Emory Univ. Sch. of Med.; Meera G. Nair, Univ. of California, Riverside

Work / Life Balance

• Table Leaders: Jennifer M. Lund, Fred Hutchinson Cancer Ctr.; Kathryn E. Hulse, Northwestern Univ.

Careers in Veterinary Immunology

• Table Leader: Alan J. Young, South Dakota State Univ.

Careers in Biotech and Industry: moving from academia to industry and vice versa

• Table Leaders: William H. Hildebrand, Univ. of Oklahoma Hlth. Sci. Ctr.; Jennifer Towne, Janssen; Antara Banerjee, Takeda; Mandy J. McGeachy, Univ. of Pittsburgh; Robert Balderas, BD Biosciences; Catherine J. McMahan, Aptevo Therapeutics; Stephen T. Haley, Immudex; Kerry A. Casey, Allen Inst. for Immunology; Yina H. Huang, Dartmouth Univ. Geisel School of Med.; Karsten Sauer, Torque Therapeutics; Tamar Boursalian, Novo Nordisk; Christopher Haines, Takeda

Careers at Government Agencies

• Table Leaders: Deborah L. Hodge, CSR, NIH; Jennifer H. Meyers, NIAID, NIH; Crystal L. Loving, USDA

NIH Study Section Insights

• Grant Writing for Fellowships/Transition Awards
  Table Leaders: Mark L. Lang, Univ. of Oklahoma Hlth. Sci. Ctr.; Virginia M. Shapiro, Mayo Clinic
• Grant Writing for PIs
  Table Leaders: Jyotika Sharma, Univ. of North Dakota.; Tessa Bergsbaken, Rutgers New Jersey Med. Sch.

The Physician Scientist: balancing clinical and research duties

• Table Leaders: Tyler J. Curiel, Univ. of Texas Hlth. Sci. Ctr.

Research from the M.D.-Ph.D. Perspective

• Table Leader: Sharon Celeste Morley, Washington Univ. Sch. of Med.

Non-Research Careers for Scientists: careers enabling scientists to advance the field away from the bench

• Scientific Publishing
  Table Leader: Nicole Beauchamp, The Journal of Immunology, AAI; Ifor R. Williams, Science Immunology
• Opportunities for Scientists in Foundations/Non-profits
  Table Leaders: Courtney R. Pinard, Career Development and Awards, AAI
• Careers in Science Policy
  Table Leaders: Lauren G. Gross, Public Policy and Government Affairs, AAI; Lauren L. Brodd, Public Policy and Government Affairs, AAI
• Technology Transfer
  Table Leaders: Gregory P. Einhorn, Greer, Burns and Crain, Ltd.; Donna Shaw, Life Science Licensing, Univ. of California, San Diego; Peter Goebel, Scripps Res. Inst.

International Opportunities in Science

• Table Leader: Maziar Divangahi, McGill Univ.; Mattias Collin, Lund Univ.

Saturday, May 11, 2019  12:30 pm – 2:30 pm  Room 33ABC  

How to Get Your Science Published: Tips on Navigating the Process

Sponsored by the AAI Publications Committee

Chairs:

• Brian D. Evavold, Univ. of Utah; Chair, AAI Publications Committee
• Eugene M. Oltz, The Ohio State Univ. Col. of Med.; Editor-in-Chief, The Journal of Immunology

Speakers:

• Brian D. Evavold, Univ. of Utah, You’ve done the research, now tell the story: advice on writing manuscripts
• Eugene M. Oltz, The Ohio State Univ. Col. of Med., Advancing your career: why you should publish in The JI
• Cathryn R. Nagler, The Univ. of Chicago, Ethics in scientific publication: a few do’s and a lot of don’ts
• Suzanne Ostrand-Rosenberg, Univ. of Utah, Successfully—and diplomatically—responding to reviewers

In this session sponsored by the AAI Publications Committee, experienced editors and authors will provide valuable insights to the processes of preparing a manuscript, responding to reviewers’ comments, and how to avoid possible ethical missteps in scientific publishing. In addition, the Editor-In-Chief of The Journal of Immunology will speak on the career benefits of publishing in The JI.

Saturday, May 11, 2019  12:30 pm – 2:30 pm  Room 30AB  

The Society for Leukocyte Biology (SLB) Symposium: Early Career Investigators: Host Defense at the Mucosal Interface

Chair:

• Ilhem Messaoudi, Univ. of California, Irvine

Speakers:

• Allison Malloy, Uniformed Services Univ. of the Hlth. Sci., Respiratory syncytial virus infection in early life results in reduced mucosal T cell responses contributing to poor tissue-resident memory T cell establishment
• Meredith Crane, Brown Univ., Post-traumatic pulmonary infection: the innate immune response protects the lung at the expense of the healing cutaneous wound
• Noah Fine, Univ. of Toronto, Canada, Flow cytometric analysis of oral neutrophils in mouse and human: identification of unique phenotypes associated with health and inflammation
• Smita Gopinath, Stanford Univ., Antibiotic-mediated antiviral immunity

Saturday, May 11, 2019  12:30 pm – 2:30 pm  Room 26AB  

International Complement Society (ICS) Symposium: Newly Defined Essential Roles of Complement

Chairs:

• Ron Taylor, Univ. of Virginia
• Sanjay Ram, Univ. of Massachusetts Med. Sch.

Speakers:

• Maciej Markiewski, Texas Tech Univ. Hlth. Sci. Ctr., Complement as an emerging target for cancer immunotherapy
• Claire Harris, Newcastle Univ., United Kingdom, Complement and disease: the changing landscape of treatment and therapy
• Anna Blom, Lund Univ., Sweden, Regulation of autophagy by complement component C3
• Viviana Ferreira, Univ. of Toledo Col. of Med., Properdin and Factor H: mechanisms of complement dysregulation in disease

Saturday, May 11, 2019  12:30 pm – 2:30 pm  

Block Symposia

Room 32ABImmunity of Asthma

Room 29ABCDImmunometabolism in Tumor Immunity and Immunotherapy

Room 30CDEInnate Immunity and Infectious Disease

Room 31ABCPathogen Control and Evasion

Saturday, May 11, 2019  3:45 pm – 5:45 pm  Room 26AB  

Chinese Society for Immunology (CSI) Symposium: Innate Immunity and Tumor Immunology

Chairs:

• Bing Sun, Shanghai Inst. of Biochemistry and Cell
• Rachel Caspi, NEI, NIH

Speakers:

• Jie Zhou, Tianjin Med. Univ., China, ICAM-1 controls development and function of ILC2
• Zusen Fan, Chinese Acad. of Sci., China, Regulatory innate lymphoid cells control innate intestinal inflammation
• Zemin Zhang, Peking Univ., China, Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing
• Long Zhang, Zhejiang Univ., China, Tumor-derived exosomes antagonize innate antiviral immunity

Saturday, May 11, 2019  3:45 pm – 5:45 pm  Room 29ABCD  

Society for Immunotherapy of Cancer (SITC) Symposium: Resisting Failure: Dissecting Mechanisms of Acquired Resistance to Cancer Immunotherapy

Chairs:

• Dario Vignali, Univ. of Pittsburgh
• Shannon Maude, Children’s Hosp. of Philadelphia

Speakers:

• Dario Vignali, Univ. of Pittsburgh, Resistance mechanisms that limit the efficacy of cancer immunotherapy
• Shannon Maude, Children’s Hosp. of Philadelphia, Combination immunotherapy to overcome resistance to CAR T cell therapy
• Ana Anderson, Brigham and Women’s Hosp., Understanding the CD8⁺ TILs response to checkpoint blockade immunotherapy
• Stanley Riddell, Fred Hutchinson Cancer Res. Ctr., CAR T cells for cancer – merging synthetic biology and immunology

Saturday, May 11, 2019  3:45 pm – 5:45 pm  

Block Symposia

Room 33ABCB Cells and the Cells that Help

Room 30CDEGut Microbiota Affect on Host Immunity

Room 30ABImmune Mechanisms of Human Disease

Room 25ABCImmune Response to Respiratory Viruses

Room 31ABCMicrobial, Parasitic and Fungal Immunology

Saturday, May 11, 2019  4:30 pm – 5:30 pm  Ballroom 20BCD  

AAI-Thermo Fisher Meritorious Career Award Presentation and Lecture

Generously supported by Thermo Fisher Scientific

Chair:

• JoAnne L. Flynn, Univ. of Pittsburgh Sch. of Med., AAI President

Award Recipient:
Kristin A. Hogquist
Univ. of Minnesota Ctr. for Immunology
Thymic selection of soldiers and peacekeepers
 
AAI President JoAnne L. Flynn and Christoph Hergersberg, Vice President of Research and Development, Thermo Fisher Scientific, will introduce the awardee and present the award immediately prior to Dr. Hogquist’s lecture.
 
The AAI-Thermo Fisher Meritorious Career Award recognizes a mid-career scientist for outstanding research contributions to the field of immunology.

Saturday, May 11, 2019  6:00 pm – 6:45 pm  Ballroom 20BCD  

Distinguished Lecture—Bruce R. Blazar: Stem cell transplantation: restoring immune balance

Bruce R. Blazar
Univ. of Minnesota
Stem cell transplantation: restoring immune balance

Saturday, May 11, 2019  7:45 pm – 10:00 pm  

Service Appreciation Reception (By Invitation Only)

Generously sponsored by BioLegend

AAI honors the dedicated member volunteers of the association—committee members, editors, abstract programming chairs, and others—who work on the membership’s behalf throughout the year by giving generously of their time in support of the AAI mission. Open (by invitation only) to 2018–2019 AAI volunteers.
 
(Badge and invitation required)

Sunday, May 12, 2019  8:00 am – 11:30 am  Ballroom 20D  

Major Symposium E: Mechanisms of Allergic Immunity

Chairs:

• Richard M. Locksley, Univ. of California, San Francisco
• Jakob von Moltke, Univ. of Washington

Speakers:

• Richard M. Locksley, Univ. of California, San Francisco, ILC2s in allergic immunity–center stage or bit players?
• Jacob von Moltke, Univ. of Washington, The missing piece: tuft cells and the intestinal type 2 immune response
• Xin Sun, Univ. of California, San Diego, Lung crosstalk to residential immune cells
• Nora A. Barrett, Brigham and Women’s Hosp., Epithelial cell remodeling in the respiratory mucosa: from form to function
• Brian S. Kim, Washington Univ. Sch. of Med. in St. Louis, The neuroimmune basis of chronic itch
• Caroline L. Sokol, Massachusetts Gen. Hosp., Control of dendritic cell migration in response to allergens

Sunday, May 12, 2019  8:00 am – 11:30 am  Ballroom 20BC  

Major Symposium F: Functional Plasticity of Innate and Adaptive Immune Cells

Chairs:

• Ananda W. Goldrath, Univ. of California, San Diego
• Jessica A. Hamerman, Benaroya Res. Inst.

Speakers:

• Ananda W. Goldrath, Univ. of California, San Diego, Reinforcing memory T cell states and fates
• Jessica A. Hamerman, Benaroya Res. Inst., Monocyte differentiation during inflammation
• Deepta Bhattacharya, Univ. of Arizona, Metabolic plasticity during hematopoietic development and B cell responses
• Jinfang “Jeff” Zhu, NIAID, NIH, Dynamic T-bet expression in CD4 T cell subset
• David G. DeNardo, Washington Univ. in St. Louis, Tumor immunity and pancreatic cancer
• Pandurangan Vijayanand, La Jolla Inst. for Immunology, Impact of genetic polymorphisms on human immune cell gene expression

Sunday, May 12, 2019  8:00 am – 10:00 am  

Block Symposia

Room 33ABCAdvances in Therapeutic Approaches for Neuroloimmunologic Diseases

Room 26ABAntigen Process and Presentation I

Room 30ABBasic Autoimmunity: B Cells

Room 25ABCHow Viruses Override the Immune System

Room 31ABCMolecular Control of CD4⁺ T Cell Life Cycle: Development, Activation, Effector, and Memory

Room 29ABCDNovel Tumor Targets and Therapies

Sunday, May 12, 2019  9:00 am – 10:00 am  Room 32AB  

Secrets for a Successful Postdoctoral Fellowship

Speaker:

• Ryan Wheeler, Director of Career, International, and Postdoctoral Services, Scripps Res. Inst.

A postdoctoral fellowship is the time to develop research skills you will need to succeed as an independent scientist. It is, however, just as important to realize that you need to prepare for a career path at the same time. This session will highlight ways of getting the most out of your postdoctoral fellowship, relating successfully with your mentor, and understanding how to use the resources available to you to ensure that your training prepares you adequately for a seamless transition into the next phase of your career.

Sunday, May 12, 2019  10:15 am – 11:45 am  Room 32AB  

International Opportunities in Science

Chair:

• Winfried F. Pickl, Med. Univ. of Vienna, Austria

Presenters:

• Mattias Collin, Lund Univ., Sweden
• Thomas Kamradt, Univ. Hosp. Jena, Germany
• Shigeo Koyasu, RIKEN, Japan
• Hanne Ostergaard, Univ. of Alberta, Canada
• Eui-Cheol Shin, Korea Adv. Inst. of Sci. and Technol., Korea

 
Working as a scientist outside of the U.S. requires curiosity, adaptability, and open-mindedness, which are valuable qualities important for success in any career. Given the international reach of science, this new session will help immunologists learn about opportunities to gain professional experience beyond the U.S. This panel features scientists employed at academic or research institutions around the globe. Panelists will discuss the postdoctoral fellowship and grant application process, the benefits of international training and employment, and the challenges in finding science-related jobs outside of the U.S. This session is open to anyone.

Sunday, May 12, 2019  10:15 am – 12:15 pm  Room 30AB  

NIH Grants Workshop: Demystifying the Grant Application Submission, Review, and Funding Processes

Chair:

• Tina McIntyre, CSR, NIH

Panelists:

• Tina McIntyre, Scientific Review Officer, III Study Section, Immunology IRG, DPPS, CSR, NIH
• Deborah Hodge, Scientific Review Officer, HAI Study Section, Immunology IRG, DPPS, CSR, NIH
• Joseph Breen, Chief, Immunoregulation Section, Basic Immunology Branch, DAIT, NIAID, NIH

This workshop will provide participants with an overview of NIH grant submission, assignment, review, and funding opportunities. Emphasis will be given to identification of the most appropriate funding agencies and mechanisms available through NIH, how to make an application “reviewer friendly”, and other strategies that contribute to applications that succeed in obtaining research funding. The workshop will also provide information on how to understand the peer review system, which is essential to competing successfully for funding, with a focus on recent changes to the review process. NIH review and program staff will provide a broad array of expertise and encourage questions from seminar participants. This workshop is open to anyone interested in learning more about preparing an NIH grant application and obtaining NIH funding. Trainees and independent investigators are welcome.

Sunday, May 12, 2019  10:15 am – 12:15 pm  Room 31ABC  

The American Society for Histocompatibility and Immunogenetics (ASHI) Symposium: HLA and Human Immunity

Chairs:

• William Hildebrand, Univ. of Oklahoma Hlth. Sci. Ctr.
• Elaine Reed, Univ. of California, Los Angeles

Speakers:

• Bjoern Peters, La Jolla Inst. for Immunology, Role of HLA in allergy
• Hannah Carter, Univ. of California, San Diego, HLA and the mutational burden of tumors
• Elaine Reed, Univ. of California, Los Angeles, Monitoring antibodies to HLA in organ transplantation
• Todd Allen, Harvard Univ., Co-evolution of HLA and HIV-1
• Melanie Hariff, Oregon Hlth. & Sci. Univ., T cell responses mediated by human MR1

Sunday, May 12, 2019  10:15 am – 12:15 pm  Room 25ABC  

Canadian Society for Immunology (CSI) Symposium: Evolving Mechanisms of Disease Tolerance in Infection and Immunity

Chairs:

• Irah King, McGill Univ.
• Lisa Osborne, Univ. of British Columbia

Speakers:

• Irah King, McGill Univ., Innate immune mechanisms of disease tolerance to intestinal helminth infection
• Maziar Divangahi, McGill Univ., Disease tolerance: a missing link in immunity to influenza virus infection
• David Schneider, Stanford Univ., Using mouse diversity as a way to probe disease tolerance to malaria infections
• Andrew Olive, Michigan State Univ., Dissecting the contributions of host resistance and tolerance in the outcome of Mycobacterium tuberculosis infection

Sunday, May 12, 2019  10:15 am – 12:15 pm  

Block Symposia

Room 30CDEInflammatory and Autoimmune Disease

Room 33ABCImmunity During Intestinal Disease

Sunday, May 12, 2019  11:15 am – 12:15 pm  Room 26AB  

AAI Vanguard Lecture

Sponsored by the AAI Minority Affairs Committee (MAC)

Chair:

• Robert J. Binder, Univ. of Pittsburgh; AAI Minority Affairs Committee Chair

Speaker:
Margaret S. Bynoe, Cornell Univ., Adenosine receptor axis in blood brain barrier (BBB) permeability regulation

Since 2003, the AAI meeting has featured a scientific lecture presented by an AAI member who is an underrepresented minority investigator noted for scientific achievement and exemplary career success.

Sunday, May 12, 2019  12:30 pm – 2:30 pm  Ballroom 20BCD  

AAI President’s Symposium

Interactions of pathogens with the immune system

Chair:

• JoAnne L. Flynn, Univ. of Pittsburgh Sch. of Med., AAI President

Speakers:

• Philana Lin, Children’s Hosp. of Pittsburgh, Tuberculosis: exceptions to every rule
• Karen A. Norris, Univ. of Georgia, Immunity in the immunocompromised host
• Robert Seder, NIAID, NIH, Intravenous vaccination as an approach for inducing protective tissue resident T cell responses against tuberculosis and malaria
• Vanja Lazarevic, NCI, NIH, Transcriptional regulation of the inflammatory response

Philana LinKaren A. NorrisRobert SederVanja Lazarevic

Sunday, May 12, 2019  12:30 pm  Ballroom 20BCD  

AAI Excellence in Mentoring Award Presentation

Chair:

• JoAnne L. Flynn, Univ. of Pittsburgh Sch. of Med., AAI President

Award Recipient:
Harvey Cantor
Dana-Farber Cancer Inst., Harvard Med. Sch.
 
AAI President JoAnne L. Flynn and Mari L. Shinohara, Duke Univ. Sch. of Med., will introduce the awardee and present the award prior to the start of the President’s Symposium.
 
The AAI Excellence in Mentoring Award recognizes exemplary career contributions to a future generation of scientists.

Sunday, May 12, 2019  12:30 pm – 2:30 pm  Room 30AB  

The Society for Glycobiology (SfG) Symposium: Harness the GLYCOme in Immunity

Chairs:

• Galit Alter, Ragon Inst. of MGH, MIT, and Harvard
• Jim Paulson, Scripps Res. Inst.

Speakers:

• Mattias Collin, Lund Univ., Sweden, Sweet revenge – bacterial immune evasion through specific antibody glycan hydrolysis
• Fikri Avci, Univ. of Georgia, Adaptive immune responses induced by HIV envelope glycoprotein
• Brian Cobb, Case Western Reserve Univ., B cell-independent glycan programming of IgG function
• Katharina Ribbeck, Massachusetts Inst. of Technol., Mucin glycans in the regulation of microbial virulence

Sunday, May 12, 2019  12:30 pm – 2:30 pm  Room 26AB  

Society for Natural Immunity (SNI) Symposium: Novel Insights into Natural Killer Cell Metabolism and Function

Chairs:

• Adelheid Cerwenka, Heidelberg Univ., Germany
• Todd Fehniger, Washington Univ. Sch. of Med.

Speakers:

• Megan A. Cooper, Washington Univ. Sch. of Med., Metabolic requirements for NK cell antiviral effector functions
• Karl-Johann Malmberg, Oslo Univ. Hosp., Norway, mTOR-dependent NK cell proliferation and subset plasticity maintains global repertoire stability during homeostasis
• Jing Ni, Heidelberg Univ., Germany, Inhibition of the Hif1a-mediated metabolic checkpoint unleashes potent NK cell anti-tumor immunity
• Carsten Watzl, Leibniz Res. Ctr., Germany, Natural Killer cells switch their killing mechanism during serial killing of tumor cells

Sunday, May 12, 2019  12:30 pm – 2:30 pm  Room 32AB  

The Obesity Society (TOS) Symposium: Roles of Immune Cells in Obesity-Associated Inflammation

Chairs:

• Gerald V. Denis, Boston Univ. Sch. of Med.
• Valentina Perissi, Boston Univ. Sch. of Med.

Speakers:

• Andrew E. Hogan, Natl. Children’s Res. Ctr., Ireland, Immune dysregulation increasing risk of comorbidities in childhood obesity
• Feng Liu, Univ. of Texas Hlth. Sci. Ctr, San Antonio, The cGAS-cGAMP-STING pathway: a molecular link between immunity and metabolism
• Naomi Ko, Boston Med. Ctr., Chronic inflammation in progression of triple negative breast cancer in disparities populations
• Guillaume Andrieu, Institut Necker-Enfants Malades, BET bromodomain targeting suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer and elicits anti-tumor immune response

Sunday, May 12, 2019  12:30 pm – 2:30 pm  

Block Symposia

Room 25ABCBasic Autoimmunity: Antigens and Innate Immunity

Room 31ABCCD8⁺ T Cell Homeostasis and Memory

Room 29ABCDCo-inhibitory/Co-stimulatory Signals in Tumor Therapy

Room 33ABCCytokine and Chemokine Control of Immunity

Room 30CDEInnate Cells in Anti-pathogen and Cytokine Responses

Sunday, May 12, 2019  3:45 pm – 5:45 pm  Room 25ABC  

National Institute on Aging (NIA) Symposium: Immune Metabolism, Inflammation, and Aging

Chairs:

• Rebecca A. Fuldner, NIA, NIH
• Cornelia Weyand, Stanford Univ.

Speakers:

• Cornelia Weyand, Stanford Univ., Metabolic fitness of T cells in aging and inflammation
• Christina Camell, Yale Univ., Tissue resident macrophages drive adipose dysfunction during aging
• Valter Longo, Univ. of Southern California, Fasting mimicking diets, immunity, and cancer
• Alison Ringel, Harvard Univ., Immunomodulatory mechanisms in the tumor microenvironment

Sunday, May 12, 2019  3:45 pm – 5:45 pm  Room 26AB  

The International Cytokine and Interferon Society (ICIS) Symposium: Cytokines in Immune-Stromal Cell Interactions

Chairs:

• Mandy McGeachy, Univ. of Pittsburgh
• Meera Nair, Univ. of California at Riverside

Speakers:

• Louise M. D’Cruz, Univ. of Pittsburgh., Regulation of immune cells in adipose tissue
• Meera Nair, Univ. of Pittsburgh, Novel Immunoregulatory Pathways in Helminth Infection through Resistin-like Molecules and Endocannabinoids
• Nunzio Bottini, Univ. of California, San Diego, Control of cytokine signaling by PTPN2 in rheumatoid arthritis
• Niki Moutsopoulos, NIDCR, NIH, Th17 immunity at the oral barrier

Sunday, May 12, 2019  3:45 pm – 5:45 pm  

Block Symposia

Room 30ABHuman Host Defense

Room 32ABMechanisms of Atopic Disease

Room 29ABCDNovel Therapeutic Approaches in Lupus

Room 33ABCViruses and Innate Immune Effectors

Sunday, May 12, 2019  4:30 pm – 5:30 pm  Ballroom 20BCD  

AAI-Steinman Award for Human Immunology Research Presentation and Lecture

Chair:

• JoAnne L. Flynn, Univ. of Pittsburgh Sch. of Med., AAI President

Award Recipient:
Steven A. Rosenberg
NCI, NIH
Lymphocytes as a drug for the treatment of human cancer
 
AAI President JoAnne L. Flynn will introduce the awardee and present the award immediately prior to Dr. Rosenberg’s lecture.
 
The AAI-Steinman Award for Human Immunology Research recognizes an individual who has made significant contributions to the understanding of immune processes underlying human disease pathogenesis, prevention, or therapy.

Sunday, May 12, 2019  6:00 pm – 6:45 pm  Ballroom 20BCD  

Distinguished Lecture—Gwendalyn J. Randolph: Clearance of molecules and cells from sites of inflammation

Gwendalyn J. Randolph
Washington Univ., St. Louis
Clearance of molecules and cells from sites of inflammation

Sunday, May 12, 2019  7:00 pm – 9:30 pm  USS Midway Museum  

IMMUNOLOGY 2019™ GALA

Generously sponsored by BioLegend

USS Midway Museum
910 N. Harbor Drive
San Diego CA

This year’s Gala will be held at the USS Midway Museum, an iconic San Diego destination. On the flight deck, attendees can experience an array of restored naval aircraft, from the workhorse of Vietnam to helicopters that picked up Apollo space missions. On deck, a band will perform dance hits surrounded by the 360-degree panoramic view of the San Diego skyline. Below, on the hangar deck, World War II aircraft can be viewed, cockpits sat in, and flight simulators experienced.

Appetizers, dinner stations, and two drinks – included in your registration fee – will be provided.

Shuttle service will be provided between the San Diego Convention Center and the Midway Museum.

Meeting Badge required for admission. Guest tickets may be purchased when registering for the meeting.

Monday, May 13, 2019  8:00 am – 11:30 am  Ballroom 20D  

Major Symposium G: Immune Responses to Emerging Viral Infections

Chairs:

• James Crowe Jr., Vanderbilt Univ.
• Sara Cherry, Univ. of Pennsylvania

Speakers:

• James Crowe Jr., Vanderbilt Univ., Human B cell responses to emerging viral infections
• Sara Cherry, Univ. of Pennsylvania, Using functional genomics to reveal new facets of antiviral immunity
• Carolyn B. Coyne, Univ. of Pittsburgh, Breaking and entering: viral infections of host barrier surfaces
• Erica Ollmann Saphire, Scripps Res. Inst., Broad and potent neutralization of Ebola and Lassa: insights from structural biology
• Adolfo Garcia-Sastre, Icahn Sch. of Med., Mount Sinai, Immune determinants of severe influenza virus infection
• Sujan Shresta, La Jolla Inst. for Immunology, Adaptive immune response to Dengue and Zika: protection or pathogenesis?

Monday, May 13, 2019  8:00 am – 11:30 am  Ballroom 20BC  

Major Symposium H: Regulating Immune Cell Metabolism to Regulate Immune Responses

Chairs:

• Jonathan Powell, Johns Hopkins Univ.
• Laurence Morel, Univ. of Florida

Speakers:

• Jonathan Powell, Johns Hopkins Univ., mTOR links TCR engagement with metabolic reprogramming to regulate T cell activation, differentiation, and function
• Laurence Morel, Univ. of Florida, Metabolic regulation of autoimmunity in lupus
• Maxim N. Artyomov, Washington Univ. Sch. of Med. in St. Louis, Itaconate immunology – from one cell to many
• Greg M. Delgoffe, Univ. of Pittsburgh, Improving immunotherapy of cancer through metabolic reprogramming
• Jennifer Martinez, NIEHS, NIH, Non-canonical autophagy mediates the immunometabolic program

Monday, May 13, 2019  8:00 am – 10:00 am  Room 30AB  

The International Society for Neuroimmunology (ISNI) Symposium: Frontiers in Neuroimmunology—Something for Everyone

Chairs:

• Amit Bar-Or, Univ. of Pennsylvania
• Nathalie Arbour, Univ. of Montreal

Speakers:

• Anna Molofsky, Univ. of California, San Francisco, Innate immune mechanisms of synapse remodeling during brain development and learning
• Francisco Quintana, Harvard Univ., Regulation of CNS inflammation by astrocytes
• Joan Goverman, Univ. of Washington, How CNS microenvironments shape CNS cell/immune cell crosstalk

Monday, May 13, 2019  8:00 am – 10:00 am  

Block Symposia

Room 26ABAntigen Processing and Presentation II

Room 31ABCB Cell Immunity

Room 29ABCDCombination Therapies for Immuno-Oncology

Room 25ABCMucosal Immunity During Infection

Room 33ABCT Cell Regulation and Function

Room 32ABTechnological Innovations I

Room 30CDETranslational Advances in Tissue-Specific Autoimmunity

Monday, May 13, 2019  10:15 am – 12:15 pm  Room 26AB  

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Symposium: Single Cell Deconstruction of Rheumatoid Synovium and Lupus Kidney by the RA/SLE Accelerating Medicines Partnership (AMP) Network

Chairs:

• Jennifer Anolik, Univ. of Rochester
• Michael Brenner, Brigham and Women’s Hosp.

Speakers:

• Jennifer Anolik, Univ. of Rochester, AMP approach and what we have learned about RA synovial pathotypes
• Soumya Raychaudhuri, Brigham and Women’s Hosp., The immune landscape in the RA synovium
• Michael Brenner, Brigham and Women’s Hosp., The stromal cell landscape in the RA synovium from single cell analysis
• Chaim Putterman, Albert Einstein Col. of Med., New insights into renal resident cells from the AMP Lupus Nephritis cohort
• Paul Hoover, Broad Inst., The immune cell landscape in lupus nephritis kidneys

Monday, May 13, 2019  10:15 am – 12:15 pm  

Block Symposia

Room 32ABBasic Autoimmunity: Role of Microbes

Room 25ABCCellular and Molecular Mechanisms of Vaccines for Enhancing Protective Immune Responses

Room 30ABRegulatory Mechanisms

Room 31ABCT Cell Receptor Signaling